Does CBD Oil Work for Migraines?

Does CBD Oil Work for Migraines?

CBD Oil for Migraines

Toward the conclusion regarding the nineteenth century, cannabis had been a mainstream treatment for preventing and relieving migraines along with other kinds of headaches. Numerous medical practioners advocated becausage of its use through to the 1940s, whenever cannabis had been taken out of the formal pharmacopeias due to its “high possibility of abuse” 1+, 2.

The current legalization of medical marijuana and CBD oil in many nations worldwide revived the almost-forgotten utilization of cannabis for headaches. But, it’s essential to notice that the only real medical use of CBD authorized by the Food And Drug Administration would be to reduce seizures in two forms of epilepsy 3.

Migraines as well as other forms of headaches are, after arthritis, the conditions that are painful commonly enhanced with CBD oil. In a study on 1500 medical CBD users, about one away from six reported struggling with headaches 4.

30% of medical cannabis users reported performing this to relieve migraines as well as other headaches in 2 studies on nearly 2500 people. But, the essential variety that is popular them had been “OG Shark,” a THC-rich hybrid strain with a low CBD content 5, 6.

This actually leaves us utilizing the question: does CBD oil alone relieve migraines along with other kinds of headaches or should you simply just take THC-containing cannabis strains to get the pain-relieving advantages? Let’s look at the technology of CBD first to obtain the answers.

So How Exactly Does It Work?

No matter what the kind, headaches include an overactivation of nerves linked to arteries into the brain (trigeminovascular system) 2, 7+.

Released vessel-widening proteins (CGRP and substance P) and messengers (NO) increase circulation, which stimulates discomfort receptors on nerve cells within the head and throat. Headaches really are a result that is direct of stimulation, while medications for headaches frequently block these receptors 2, 7+.

Boosts Normal Cannabinoids

The system that is endocannabinoid consists of two receptors: CB1 and CB2. Both THC from cannabis together with cannabinoids naturally created by the physical human body, such as for instance anandamide, decrease pain by activating these receptors 8, 10, 11.

CBD is significantly diffent: it blocks in place of activates these receptors. Nonetheless, it prevents anandamide from being separated. Interestingly, a theory from the very very early century that is 21st migraines (along with other chronic discomfort conditions) with low anandamide levels 12, 10, 13, 14, 15.

In reality, further studies revealed that folks – and specially ladies – with migraines usually have less anandamide within the fluid that is spinal platelets 16, 17, 18.

The exact same ended up being real in individuals with headaches from overusing painkillers; when they withdrew through the medications, that they had less anandamide breakdown and pain 19, 20.

Individuals with chronic headaches have actually reduced anandamide levels and greater CGRP and NO production. CB1 activation by anandamide and artificial cannabinoids obstructs the manufacturing of CGRP with no, which prevents (trigeminovascular) nerve overstimulation and headaches 21, 22, 23, 24, 16.

Activates Serotonin Receptors

As hinted above, anandamide reduces migraines by activating CB1. In rats, blockers regarding the serotonin receptor 5HT(1B/1D) prevented anandamide from activating CB1. This receptor has a well-known part in relieving headaches and its own activators (called triptans) are traditional drugs for migraines 25, 26, 27.

CBD may reduce neurological discomfort by activating another serotonin receptor (5HT1A), which will be found in the back in place of in the mind 28|relative head28, 29, 30, 31.

Activates the TRPV1 Receptor

CBD and anandamide can bind to a receptor involved with inflammatory pain (TRPV1). Its activation causes the production of CGRP, which increases the flow of blood towards the nerves that are trigeminal. This shows that CBD could potentially cause headaches 14, 32, 33, 34, 35.

Nonetheless, repeated TRPV1 activation reduces sensitiveness to pain. Indeed, a nose spray aided by the chili pepper compound capsaicin – which also activates this receptor – relieved migraines in a tiny test on 8 people 14, 36+.

Obstructs Glutamate

Alterations in eyesight, flexibility, or speech called aura typically precede migraine assaults. These migraine harbingers are brought on by glutamate overactivation within the mind. Anandamide, THC, and artificial cannabinoids block glutamate receptors, suggesting they assist in preventing auras 2, 37, 38, 39, 40.

Reduces Inflammation and Autoimmunity

Autoimmune diseases may trigger migraines along with other kinds of headaches when they cause irritation associated with the blood vessels within the mind. Indeed, conditions such as for example multiple sclerosis, lupus, Sjцgren problem, and syndrome that is antiphospholipid connected with regular headaches 41.

CBD may relieve headaches in individuals with these conditions through its strong activity that is anti-inflammatory. The production is reduced by it of pro-inflammatory messengers (such as for example IL-1beta, IL-6, TNF-alpha, IFN-gamma. NO, and prostaglandins) while enhancing the degrees of the anti inflammatory cytokines IL-4 and IL-10 43, 44, 45, 46, 47.

Alternatively, it would likely stop the signs and symptoms of autoimmune disorders by curbing the response that is immune. For example, CBD prevented T cells from building and multiplying up within the minds of mice with multiple sclerosis – while reducing the autoimmune-linked Th17 reaction 48, 49.

Whenever Does It Work?


In a research on over 100 individuals with migraines making use of medicinal cannabis (with both CBD and THC), 85% reported paid down pain and migraine regularity 50.

In a medical test on 79 people who have chronic migraines, a planning with additional CBD than THC prevented sincesaults because effectively as being a migraine medication (amitriptyline). a dose that is additional the assaults paid down pain. Likewise, 3 cannabis that are heavy started having migraines once they stopped; one got rest from smoking again 51.

THC may account fully for a great element of these effects. THC alone prevented migraine assaults and paid off pain in rats. In comparison, its overuse could have the opposing impact: high doses increased sensitivity to duplicated neurological stimulation – a suspected migraine trigger 53, 54.

Taken together, there’s no proof that CBD oil improves migraines. Studies in rats also claim that THC in the place of CBD could be the cannabinoid accountable for the pain sensation relief noticed in people cannabis that are using for migraines.

Other kinds of Headaches

In study on over 100 individuals with cluster headaches, 45% utilized cannabis but just 25% skilled relief while 22percent felt even worse 55.

Within one report, leisure marijuana and synthetic THC (dronabinol) enhanced regular cluster headaches in an adolescent. The advantage ended up being most most likely from THC, maybe not CBD 56.

In an effort on 13 individuals with headaches from overusing painkillers, cannabis preparations pain that is reduced. But, the planning utilizing the THC content that is highest (oil) was more beneficial. In accordance with this, an artificial compound that is THCnabilone) reduced pain additionally the importance of painkillers a lot better than ibuprofen in another trial on 26 individuals 57, 58.

Within the term that is short THC as well as other CB1 activators additionally relieved headaches from painkillers in rats. Nevertheless, their repeated use increased sensitiveness to discomfort meaning that is might trigger migraines 54.

Both marijuana that is medical a synthetic THC substance (dronabinol) relieved headaches in 2 ladies with a high stress into the brain (pseudotumor cerebri) 59+, 60.

A couple of clinical and animal studies recommend that CBD is possibly inadequate for cluster headaches and headaches from overusing painkillers. THC is apparently the only cannabinoid providing some treatment, however the proof continues to be restricted.


There are no clinical studies testing CBD alone for headaches. A lot of them utilized cannabis preparations with adjustable quantities of THC and CBD.

A lot of people with migraines prefer THC-rich cannabis strains. Plus, synthetic THC analogs had been additionally effective. This shows that migraine relief requires direct activation that is CB1 only THC will probably achieve. Having said that, CBD may somewhat help by boosting anandamide levels.

CBD Oil Dosage for Migraines


Because CBD is certainly not authorized for migraines or other kinds of headaches, there’s no formal dosage. There’s no confirmed dosage either because CBD alone hasn’t been tested in medical trials. The only study assessing a item greater in CBD than in THC (9% vs 0.4%) used a dosage of 200 mg (providing 18 mg CBD) per day. But, we can’t rule out of the share of the THC content to your results 51+.

We could also calculate dose on the basis of the directions from manufacturers and users.

One maker of the commercial oil specifically formulated for migraines recommends 1 mL (providing 33 mg CBD) per day.

Natural health blog sites and users choose reduced doses (15-25 mg/day). They often suggest beginning with a dose that is low increasing it until noticing pain-relieving results. It’s crucial for this gradually, since high doses may trigger migraines while increasing hassle intensity 61.

Whatever the case, don’t try CBD oil or other unverified therapies for migraines and headaches without consulting your medical professional ahead of time. Consult with your medical professional if CBD oil can help for you personally and exactly what dose and delivery form may be better for you personally.

Simple tips to make use of

CBD oil is available in different forms. Your type of option may rely on your form of headache 62+:

  • Vaping, lips sprays, and oil tinctures are absorbed quickly and offer pain relief that is temporary. They may operate better for cyclically-arising headaches such as group headaches.
  • Capsules, edibles, and teas discharge the CBD more gradually however their effects go longer. They may be better for conditions with constant discomfort such as for example headaches from overusing painkillers.

Although migraine discomfort is certainly not constant, slow-release CBD forms might be more beneficial (predicated on CBD’s relationship with all the TRPV1 receptor). Acute CBD doses may trigger attacks that are migraine duplicated doses relieve pain perception.

Anecdotal proof from internet forums advises using cannabis that are medicinal just after beginning to sense the start of a migraine or cluster hassle attack 61.

Best CBD Oil for Migraines

As well as picking a CBD oil modified to your budget (you might want to determine the cost per mL or mg to compare brands that are different, it’s also advisable to assess the item quality. Read here on how to pick the CBD oil that is best.


The opinions indicated in this section are entirely those of CBD oil users whom may or might not have medical or clinical training. Their reviews usually do not express the viewpoints of SelfHacked. SelfHacked will not endorse any product that is specific solution, or therapy.

Try not to consider individual experiences as medical advice. Never ever postpone or disregard searching for expert advice that is medical your physician or other qualified medical providers due to one thing you’ve got continue reading SelfHacked. We recognize that reading specific, real-life experiences could be a helpful resource, however it is never ever an alternative for health-related advice, diagnosis, or therapy from a qualified doctor.

The essential headache that is common among CBD oil users was migraine, followed closely by stress frustration, and hassle from painkiller overuse or conditions such as fibromyalgia. Many of them had been pleased and reported pain relief that is good. The users reported some added benefits such as improving sleep quality and curbing anxiety in several cases.

Some users reported that the oil didn’t work that it made them drowsy and fatigued for them or. CBD oil also caused headaches in certain social individuals using it at high doses.


Many people with migraines utilize THC-rich cannabis strains, although some choose CBD oil. No medical research reports have yet tested CBD oil alone for headaches or migraines.

Animal studies reveal that CBD oil may alleviate headaches – but just within the run that is long not likely along with THC.

Sudden surges in CBD, such as for example from vaping, might cause migraines. But taken long-lasting, CBD may decrease pain perception and stop auras that are migraine. It mainly functions by boosting your cannabinoid that is natural bliss.

CBD oil are often an alternative for those who have migraines and headaches from autoimmune diseases like lupus and numerous sclerosis. In such instances, it likely helps by reducing brain suppressing and inflammation autoimmunity.

Go with capsules or edibles and simply take them every for the best results day.

Vendors offer CBD oil on Amazon, but many of them try not to satisfy quality criteria. Some don’t even specify the CBD content within their services and products, while other people offer hemp oil with little or no CBD. A lot of these vendors are never to be trusted.

We suggest the brand that is following which specifies quality procedures and CBD content within their items:

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